PLINEST One 5x4ml

Attention! The product is to be used only by qualified medical personnel.


Availability: 3 in stock

PLINEST One 5x4ml

SKU 11833 Categories ,

The bioreparant Plinest One is a unique development of the Italian pharmaceutical concern Mastelli. The universal preparation based on polydesoxyribonucleotides (PDRN) is designed for intradermal injection and is used to increase skin elasticity in different areas of the face and body. The cosmetic product is suitable for removing dryness and flabbiness, reducing the signs of skin aging as well as for the prevention of aging.

Main characteristics of Mastelli Plinest One, preparation for biorevitalization on the basis of polynucleotides 4 ml

The product for biorevitalization, bioreparation is available for sale in the form of a transparent sterile gel. Its manufacturer, Mastelli, is known among cosmetologists as the creator of a wide range of products based on polynucleotides – injectable biostimulants, professional skin care cosmetics and nutraceutical nutritional supplements.

Plinest One contains PDRN at a concentration of 2 mg/ml. Mastelli’s patented polydeoxyribonucleotide PN-HPT is derived from the milk of salmon. The long-chain polymer is a fragment of cell DNA from the fish body.

Intradermal injection of polynucleotide:

  • promotes restoration of damaged DNA in dermal cells;
  • activates fibroblast polyproliferation, synthesis of endogenous hyaluronic acid and collagen;
  • strengthens skin tissues by increasing production of fibronectin, an adhesive protein of the extracellular matrix, which acts as a “molecular glue”;
  • it enhances the growth of new blood vessels, which improves oxygenation and nutrition of tissues.

In addition, PDRN has a significant anti-inflammatory and antioxidant effect. Its regenerative properties surpass those of hyaluronic acid. The price for Plinest One is more than affordable, considering the large volume of the product (4 ml/8 mg) and the high effect of PDNR already after the first session.

On our website you can buy Plinest One both separately in vials and in boxes of 5 vials of 4 ml. Needles are not included.

Application area of Mastelli Plinest One, preparation for biorevitalization on the basis of polynucleotides 4 ml

The injection product is indicated for use in the area:

  • face;
  • neck, decollete;
  • back of the hands;
  • abdomen;
  • thighs;
  • buttocks.

The indications for biorevitalization, bioreparation with Plinest One are:

  • excessive dryness of the skin;
  • flabbiness, atonic epidermis;
  • scars;
  • striae;
  • skin “sagging”.

The product is suitable for reduction of destructive age-related changes, skin tightening after weight loss and childbirth. However, injections are recommended for patients at least 18 years old.

Procedure protocol

The manipulation can only be carried out by doctors, cosmetologists who have been trained to work with the product and who have a certificate confirming their qualifications. Ampoules of gel are opened only in the presence of the patient.

The product is injected into the dermis with a 30G needle. For injections, the following techniques are used:

  • linear;
  • papular;
  • classical (single injections);
  • lattice;
  • fan.

Skin is disinfected before the injections, and then the antiseptic is washed off with saline solution. The course consists of 3 procedures carried out with 2-week intervals. In case of significant age-related changes, the number of sessions may be more. A supporting course is prescribed on an individual basis.

It is possible to perform bioreparation with non-invasive methods, such as ionophoresis, electroporation, hydroelectrophoresis.

Result of application

The effect of biorevitalization, bioreparation is already visible after the first session. Due to the high degree of gel purification from proteins, lipids and polysaccharides, the procedure does not cause any side effects. Needle marks heal in 2-4 days. During this time, it is recommended to minimize manual contact with the injected areas, refrain from visiting saunas and swimming pools, do not drink alcohol, as it activates blood circulation and can provoke the formation of haematomas. Sunbathing is forbidden for two weeks, and exposed areas should be protected from the sun with sunscreen with UV filters.


Biorevitalizing injections on the face or body with Plinest One are not indicated if:

  • cancer;
  • allergies to fish products;
  • previous history of anaphylactic shock;
  • diabetes mellitus in decompensation;
  • epilepsy, mental disorders;
  • autoimmune diseases;
  • low blood clotting;
  • dermatosis.

Temporary contraindications to the procedure are pregnancy and lactation, colds and other infectious diseases, taking blood thinning medications.

Storage and transportation

The preparation for biorevitalization is kept away from sources of bright light and heat. The ideal place is a darkened room at the temperature of 20C-25C. Do not freeze!

  • Indications for use

    Skin flabbiness
    Postacne, scars

  • Composition features


  • Hyaluronic acid concentration

    does not contain

  • Volume (ml)

    4 ml

  • Duration of action

    up to 6 months





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