Mastelli Plinest (1x2ml) for biorevitalization based on polynucleotides

The product may only be used by professionals.

By making a purchase, you declare that you are a doctor or cosmetologist trained in aesthetic medicine.

  • Composition features: polynucleotides
  • Hyaluronic acid concentration: does not contain
  • Volume (ml): 2 ml


Availability: 23 in stock

Mastelli Plinest (1x2ml) for biorevitalization based on polynucleotides

SKU 11830 Categories ,

The preparation Plinest, created in the laboratories of the famous Italian pharmaceutical company Mastelli, is a unique tool for regenerating the skin and slowing down aging processes. The preparation based on polydesoxyribonucleotides (PDRN) has a broad spectrum of action and is used as a cocktail for smoothing wrinkles, smoothing scars and improving skin tone.

Main characteristics of Mastelli Plinest, preparation for biorevitalization on the basis of polynucleotides 2 ml

The product for biorevitalization and bioreparation is a viscoelastic gel without color and odor. Unlike its “neighbor” in the line, Mastelli Newest, this product does not contain hydrophilic hyaluronic acid. The active components of Plinest are polynucleotides synthesized from the milk of the salmon family fish. Their concentration in the bioreparant is 20 mg/ml.

The long-chain polymer is a fragment of salmon DNA and is similar in structure to human DNA. PDRN serves as a material for the synthesis and “repair” of the skin’s own DNA in damaged areas.

In addition, polynucleotides:

  • stimulate fibroblast polyproliferation and activate collagen production;
  • promote the formation of new blood vessels, thereby increasing the supply of oxygen to the cells;
  • activate the synthesis of fibronectin – a protein of the extracellular matrix responsible for “gluing”, and therefore strengthening tissues;
  • protect cellular DNA from damage caused by exposure to ultraviolet light;
  • have anti-inflammatory properties.

During the production of the bioreparant PDRN undergoes multistage purification from impurities of proteins, lipids and polysaccharides, so that the product has high biocompatibility with human tissues and does not cause complications. High efficiency and favorable effect of polynucleotides on skin tissues have been proved by a number of clinical trials.

Mastelli Plinest can be bought on our website in ready-to-use sterile syringes of 2 ml. The kit includes 2 30G ½ needles.

Application area of Mastelli Plinest, preparation for biorevitalization based on polynucleotides 2 ml

Injections of a bioreparantine based on polynucleotides are performed in the following areas:

  • face, including areas with delicate skin around the eyes and lips;
  • neck;
  • decollete;
  • back of the hands;
  • certain areas of the body where there are stretch marks.

The indications for the procedure are:

  • dull skin color;
  • flabbiness, decreased skin turgor;
  • enlarged pores;
  • wrinkles and folds;
  • scars, including post-acne;
  • dark circles under the eyes;
  • frequent skin inflammations;
  • photo- and chronoaging.

The preparation is recommended for women and men from the age of 25. Bioreparation can be performed as an independent procedure or as a part of a complex anti-age program together with chemical peeling, apparatus and other cosmetic manipulations.

Procedure protocol

The product is available for sale only to cosmetologists. Injections can only be performed by specialists who have been trained and certified to work with Plinest. For intradermal injection of the gel, the following techniques are used:

  • papular;
  • linear;
  • fan;
  • reinforcement technique.

Bioreparation is carried out during a course of 4-5 sessions, with an interval of 10-14 days. Plinest injections can also be combined with intradermal injection of Ialest by Mastelli. The second course may be prescribed after 6-12 months.

Result of application

The effect of bioreparation is already visible after the first treatment. The relief and tone of the skin are smoothed, the degree of age-related changes is reduced. Since the product does not contain hydrophilic hyaluronic acid, there is no post-procedure swelling. Injection marks heal in 2-4 days.

On the day of the session you should refrain from the use of decorative cosmetics and minimize hand contact with the injected areas. For 2 weeks it is not recommended to be exposed to the sun, so as not to provoke pigmentation, to visit sauna and swimming pool, it is desirable to limit physical activity.
To prolong the biorevitalizing effect, patients are advised to use Mastelli home care creams.


Intradermal injections are contraindicated in:

  • pregnancy, breastfeeding;
  • patients under 18 years of age;
  • tendency to scar tissue;
  • diabetes mellitus;
  • blood clotting disorders;
  • autoimmune disorders.

The session should be postponed if there is an inflammatory process in the patient’s body, if there are pockets of infection or non-healing wounds on the skin in the area of the planned injections.

Storage and Transportation

Store at 2 to 25 degrees Celsius. Do not freeze or damage the package. Period of validity of the product is indicated on the package.


  • Main characteristics
  • Indications for use

    Hair loss
    Skin flabbiness
    Fine lines
    Skin sagging
    Dry and flaky skin

  • Composition features


  • Hyaluronic acid concentration

    does not contain

  • Duration of action

    up to 6 months

  • Layers of the dermis






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